BiOrion is a Dutch clinical stage biopharmaceutical drug discovery company engaged in developing targeted therapeutics and companion imaging diagnostics for fibrotic diseases. These diseases include cardiac fibrosis and hepatic fibrosis, and fibrosis-associated cancers such as colorectal cancer. BiOrion's platform and drug development engine is based on proprietary PDGF-ß-receptor binding bicyclic peptides that act as targeting vehicles for diagnostic PET radionuclides and (existing) anti-fibrotic therapeutics.

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Fibrotic tissue is characterized by abundant myofibroblast-specific overexpression of the PDGF-ß-receptor. This over-expressed receptor allows myofibroblast-specific targeting and delivery of antifibrotic drugs, thereby leaving healthy tissues unaffected. After binding of BiOrion’s peptide-conjugate to the receptor, the complex is internalized and accumulated rapidly and, dependent on the payload, can exert its intracellular effect.

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BiOrion has two active development programs. In the non-invasive diagnostic imaging program BOT501 the bicyclic peptide is conjugated to a 68Ga-PET radionuclide. BOT501 is developed to identifying and stratifying patients with colorectal cancer, hepatic fibrosis or cardiac fibrosis as well as following up disease-specific targeted therapy. In the therapeutic program BOT501 the bicyclic peptide is conjugated to 177Lu- radionuclide. This molecule is developed for targeted RadioLigand Therapy for patients with metastatic colon cancer CMS4.

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Innovation in Fibrosis Technology

BOT501 and BOT191, Companion Imaging Diagnostics and Targeted Therapeutics for Fibrosis



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