Company
BiOrion is a Dutch clinical stage biopharmaceutical drug discovery company engaged in developing targeted therapeutics and companion imaging diagnostics for fibrotic diseases. These diseases include cardiac fibrosis and hepatic fibrosis, and fibrosis-associated cancers such as colorectal cancer. BiOrion's platform and drug development engine is based on proprietary PDGF-ß-receptor binding bicyclic peptides that act as targeting vehicles for diagnostic PET radionuclides and (existing) anti-fibrotic therapeutics.
Read moreTarget
Fibrotic tissue is characterized by abundant myofibroblast-specific overexpression of the PDGF-ß-receptor. This over-expressed receptor allows myofibroblast-specific targeting and delivery of antifibrotic drugs, thereby leaving healthy tissues unaffected. After binding of BiOrion’s peptide-conjugate to the receptor, the complex is internalized and accumulated rapidly and, dependent on the payload, can exert its intracellular effect.
Read morePipeline
BiOrion has two active development programs. In the non-invasive diagnostic imaging program BOT501 the bicyclic peptide is conjugated to a 68Ga-PET radionuclide. BOT501 is developed to identifying and stratifying patients with colorectal cancer, hepatic fibrosis or cardiac fibrosis as well as following up disease-specific targeted therapy. In the therapeutic program BOT501 the bicyclic peptide is conjugated to 177Lu- radionuclide. This molecule is developed for targeted RadioLigand Therapy for patients with metastatic colon cancer CMS4.
Read moreInnovation in Fibrosis Technology
BOT501 and BOT191, Companion Imaging Diagnostics and Targeted Therapeutics for Fibrosis
News
BiOrion Technologies receives an EFRO TENDER VALORISATIE 2017 grant for its € 1.0 million cardiac fibrosis imaging program.
Groningen, The Netherlands, December 14, 2017 An EFRO TENDER VALORISATIE 2017 grant of a EUR 1.0 million cardiac …Read More »BiOrion Technologies, Zealand Pharma and Akademiska Sjukhuset Uppsala receive a EUROSTARS grant for their € 1.8 M fibrosis imaging program BONIFIB
September 26, 2017 Groningen, The Netherlands, September 26, 2017 The EUROSTARS grant of a EUR 1.8 million fibrosis imaging …Read More »BiOrion concluded investment by Carduso Capital
PRESS RELEASE Groningen, The Netherlands, November 11, 2016 BiOrion Technologies BV has raised funding from Carduso Capital for …Read More »
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