Cardiac Fibrosis

Cardiac fibrosis is an abnormal wound healing process in the heart that often results from acute myocardial infarction (MI) and is seen in the progression to heart failure. Improvements in the treatment of MI have led to declining rates in mortality and morbidity in recovering post-MI patients. However, concomitant with improved patient outcome, greater numbers of patients survive the acute phases of MI and undergo the processes associated with myocardial tissue healing. This results in abnormal expansion of myocardial extracellular matrix (ECM) interstitium with many ultimately succumbing to ventricular dysfunction and, depending on the size of the initial infarct, development of congestive heart failure.